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Overview
The mission of the University of Kentucky CCTS pilot program is to offer opportunities and resources necessary to support innovative intervention, early stage and collaborative research approaches in clinical and translational studies and to promote the development of new methodologies and tools relevant to the health challenges and disparities faced by the citizens of Kentucky, Appalachia and other rural population.
Eligibility
Clinical and translational trainees or researchers (please see specific award announcement for additional information).
Pilot Grant Funding Opportunities
Attention Investigators:
The Center for Clinical and Translational Science Pilot Research Program is calling for applications.
Applications will be accepted and reviewed according to the following schedule
| Call for Applications | Letter of Intent & Biosketch Due | LOI Finalists Notified | Full Application Due | Funding Decision |
| January 25, 2013 | February 18, 2013 | March 18, 2013 | April 22, 2013 | May 27, 2013 |
The categories of awards will be as follows:
The purpose of this funding mechanism is to provide a new opportunity and resources to support innovative, collaborative research relevant to the health challenges and disparities faced by the nation. The funding for these pilot studies is derived from the CCTS program in partnership with other UK centers, and with other universities in the Appalachian Translational Research Network (ATRN). Hence, some of the awards will give priority to studies with a disease focus, community engagement, or with collaboration between UK and other ATRN universities.
Investigators at all stages of career development, junior, middle level, and senior are eligible to apply to the following categories of awards:
COMMUNITY ENGAGEMENT AWARD
Applications are encouraged from investigators using Community Engagement methodologies. Priority will be given applications that utilize CCTS research infrastructure housed at
UK Centers for Rural Health in Hazard and Morehead, KY. The maximum award will be $25,000 which must be spent over 18 months.
DISEASE FOCUSED
- JOINT CCTS-MARKEY CANCER CENTER PILOT AWARD
The UK Markey Cancer Center will contribute to this program, and studies related to cancer are encouraged. Translational projects with a focus on Appalachian Eastern Kentucky will be given high priority. Potential studies could range from basic mechanisms that contribute to the high incidence of cancer in Appalachia to population-based cancer prevention and control studies. The maximum award will be $50,000 which must be spent over 18 months.
- JOINT CCTS-SANDERS BROWN CENTER ON AGING PILOT AWARD
The UK Sanders Brown Center on Aging will contribute to this program, and studies that stimulate innovation and dynamic basic, translational, and/or clinical research relevant to both aging and Alzheimer's disease are encouraged. The maximum award will be $50,000 which must be spent over 18 months.
- JOINT CCTS-BARNSTABLE BROWN DIABETES AND OBESITY CENTER PILOT AWARD
The UK Barnstable Brown Diabetes and Obesity Center will contribute to this program, and applications are encouraged that address translational aspects of diabetes and/or obesity. The maximum award will be $50,000 which must be spent over 18 months.
- JOINT CCTS-SPINAL CORD AND BRAIN INJURY RESEARCH CENTER PILOT AWARD
The UK Spinal Cord and Brain Injury Research Center (SCoBIRC) will contribute to this program, and applications are encouraged that address injuries to the spinal cord and brain that result in paralysis or other loss of neurologic function. The maximum award will be $50,000 which must be spent over 18 months.
PARTNERSHIP WITH OTHER ATRN INSTITUTIONS
- UNIVERSITY OF KENTUCKY AND UNIVERSITY OF CINCINNATI COLLABORATIVE GRANT
Priority will be given to applications that involve collaboration between investigators at UK and the University of Cincinnati (UC) and Cincinnati Children’s Hospital (CCHMC). This project will involve an equal contribution from each institution and will require Co-PI’s from each institution.
- UNIVERSITY OF KENTUCKY AND MARSHALL UNIVERSITY COLLABORATIVE GRANT
The purpose of this funding mechanism is to encourage collaborative projects between multi–institutional research teams capable of performing highly innovative, extramurally fundable research that will continue to contribute to the health and wellbeing of our citizens.
- UNIVERSITY OF KENTUCKY AND WEST VIRIGINIA UNIVERSITY COLLABORATIVE GRANT
Priority will be given to applications that involve collaboration between investigators at UK and West Virginia University. This project will involve an equal contribution from each institution and will require Co-PI's from each institution.
In order to qualify for this round of funding the CCTS must receive a Letter of Intent (LOI) (see attached template) and biosketch. Please forward the LOI and biosketch to Elodie Elayi via email (Elodie.elayi@uky.edu) no later than Monday, 5: 00 pm, February 18, 2013.
To apply:
Access the CCTS Pilot Project Call for Application and LOI at:
UK CCTS Pilot Call 2013
LOI template
Drug Discovery and Development Core Funding opportunity
Applications will be accepted and reviewed according to the following schedule
| Call for Applications | Letter of Intent | Committee Decision for Full Application Request | Application | Funding Decision |
| Mar 15, 2013 | April 5, 2013 | May 1, 2013 | July 1, 2013 | July 31, 2013 |
Priorities for funding:
The primary objective of this RFA is to provide funding to support new drug discovery and development research with the goal of augmenting the translation of scientific discoveries to therapeutic development. Specifically, the purpose is to assist in the transition from biology and target identification to clinical targets and to facilitate the transition of discovery through development and delivery to all phases of clinical trials and subsequent commercialization. The areas of emphasis include:
The primary objective of this RFA is to provide funding to support new drug discovery and development research with the goal of augmenting the translation of scientific discoveries to therapeutic development. Specifically, the purpose is to assist in the transition from biology and target identification to clinical targets and to facilitate the transition of discovery through development and delivery to all phases of clinical trials and subsequent commercialization. The areas of emphasis include:
Pilot studies which generate critical preliminary data that will enhance the competitiveness of extramural funding for drug discovery and development.
Pilot studies addressing an important question in translational drug discovery and development research that impacts human health.
Multidisciplinary research including at least two investigators, representing the basic, clinical and/or applied sciences with an emphasis on the translation towards commercialization of new drug discovery and development.
Funding : Up to $50,000 in total direct funding may be requested for a 12-month project. With adequate progress the possibility of a renewal for a second $50,000 in total direct and an additional 12 months will be considered.
In order to qualify for this round of funding the CCTS must receive a Letter of Intent (LOI) and biosketch.
Please forward the LOI and biosketch to Charolette Garland (257-5265, cawgarland@uky.edu) by April 5, 2013.
To apply:
Access further information and the Mini-Grant Application at:
CCTS Drug Discovery and Development Core RFA
Community Engagement Mini Grant Awards
The University of Kentucky, Center for Clinical and Translational Science (CCTS) Community Engagement Program is requesting applications from community partners for funding to support health outreach projects. Funds will be used to support small-scale evidenced-based or evidence-informed health outreach projects that contribute to the reduction of health disparities in Appalachian communities in Kentucky by developing, implementing, and evaluating community-based projects **Note: Eligible community agencies/coalitions must have 501c3 status or a designated lead fiscal agency (health agency or non-profit). University of Kentucky faculty and staff are not eligible for this award program as project leader/applicant.
To apply:
Access further information and the Mini-Grant Application at:
CCTS Community Engagement Mini Grant Award 2013 Application
Full Application Submission deadline: Friday, April 12, 2013
CATalysts and Interdisciplinary Research
Investigators developing interdisciplinary pilot projects have access to the CCTS CATalysts who are a team of experts in different fields of clinical and translational research such as drug development, novel methodology and biomedical engineering. It is critically important that new ideas benefit from the guidance of these experts prior or in conjunction with protocol development.
Please visit "What is a CATalyst" for a list of our CATalysts, their areas of expertise and how they can assist with pilot projects development.
Summer 2012 Awardees
| Investigator | Pilot Proposal Title | College/Dept. | Research Centers/partners |
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Bradley, Luke
PhD
| Sequence and Size Optimization of DNSP-11 | Molecular and Cellular Biochemistry | UKCCTS |
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Campbell, Kenneth
PhD
| Mechanical unloading improves the function of failing hearts | Physiology | UKCCTS |
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Gelfand, Bradley
PhD
| Regulation of the Rnase Dicer in human atherosclerosis | Ophthalmology and Visual Sciences | UKCCTS |
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Jicha, Gregory
MD, PhD
| Telemedicine-based, multidisciplinary-team, intervention to reduce unnecessary hospitalizations and healthcare costs in Appalachia KY skilled nursing facilities | Neurology | UKCCTS |
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Marti, Frances
PhD
| Compromised differentiation of induced Regulatory T cells of asthma patients. Effects of Retinol. | Microbiology and Immunology | UKCCTS |
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Van Horne, Craig
MD, PhD
| A pilot study to evaluate the safety and feasibility of implanting autologous peripheral nerve grafts into the substantia nigra of subjects with Parkinson's Disease (PD) undergoing deep brain stimulation (DBS) surgery and treatment | Neurosurgery | UKCCTS |
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Yang, Lin
PhD
| A computer Aided Automatic Analysis and Assessment of Morphological Characteristics of Muscle Fibers | Biomedical Informatics | UKCCTS |
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Summer 2012 Awardees
Joint Pilot Projects
| Investigator | Pilot Proposal Title | College/Dept. | Research Centers/partners |
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Esser, Karyn
PhD
| Realigning circadian rhythms to improve health | Physiology/Center for Muscle Biology | UKCCTS- Barnstable Brown |
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King, Victoria
PhD
| SAA Association with apoB-containing lipoproteins in Metabolic Syndrome is Pro-Atherogenic | Internal Medicine/Cardiovascular Medicine | UKCCTS- Barnstable Brown |
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Wang, Wangxia
PhD
| Role of peroxisome proliferator-activated receptors (PPARs) on the regulation of microRNAs in neuronal cells | Sanders-Brown Center on Aging | UKCCTS- Sanders Brown |
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D'Orazio, John
MD, PhD
| Defining the regulation of UV-induced MSH production in the skin | Microbiology and Immunology | UKCCTS-Markey Cancer |
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O'Connor, Kathleen
PhD
| Pilot Studies to develop small-molecule inhibitors of cancer cell migration and invasion | Molecular and Cellular Biochemistry | UKCCTS-Markey Cancer |
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Villano, John
MD, PhD
| Concurrent anti-angiogenic and cytotoxic chemotherapy to standard WBRT for RPA class II brain metastases from NSCLC | Ophthalmology and Visual Sciences | UKCCTS-Markey Cancer |
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Yang, Lin, PhD/Kun, Huang, PhD
| Integrated Morphological and Genome Analysis for Computer-Aided Diagnosis and Computer-Intervened Personalized Treatment for Lung Cancer | Biomedical Informatics | UKCCTS-OSUCCTS |
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Nalini, Santanam
PhD
| MicroRNA Fingerprint in Women with Endometriosis and Pain | Pharmacology, Physiology, & Toxicology | UKCCTS- Marshall University |
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Naz, Rajesh K., PhD/Misung, Jo, PhD
| Investigation of ovarian transcription factors, chemokines, and proteases in women with polycystic ovarian disease | Obstetrics Gynecology | UKCCTS- West Virginia University |
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Fall 2011 Awardees
Joint Pilot Projects
| Investigator | Pilot Proposal Title | College/Dept. | Research Centers/partners |
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Johnson, Nancy E.,
DrPH, MSPH, CIH
| Lung Cancer in Appalachian Kentucky: Elemental Composition of Soils Accessible to Residential Interiors and Distribution Across Soil Fractions, sized 250 μm, 10 μm, and 2.5 μm | Public Health | UKCCTS-Markey Cancer |
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Wilcock, Donna,
PhD
| A Study on the Serum and Brain Markers of Inflammation in Alzheimer’s Disease | Medicine | UKCCTS-Sanders Brown |
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Powell, David K.,
PhD
| Is Aerobic Fitness Associated with White Matter Integrity and Cerebral Perfusion in Healthy Older Adults? | Medicine | UKCCTS-Sanders Brown |
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Schoenberg, Nancy, PhD (UK)/Katz, Mira L., PhD (OSU)
| Leveraging Social Networks to Increase Cancer Screening in Appalachia | Behavioral Science | UKCCTS-The Ohio State University |
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Claudio, Pier Paolo, PhD (Marshall)/Rolf J. Craven, PhD (UK)
| Phase-I Clinical Trial Investigation of Sensitivity to Chemotherapy in Appalachian Lung Cancer Patients | Bioch/Molec.&Biomed. | UKCCTS-Marshall University |
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Xie, Jingwei,
PhD
| Biomimetic Nanofiber Scaffolds Seeded with Adipose-derived Stem Cells for Rotator Cuff Injury Repair | Institute for Interdisciplinary Research | UKCCTS-Marshall University |
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Fall 2011 Awardees
| Investigator | Pilot Proposal Title | College |
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Stoops, William,
PhD
| An Investigation of Contingency Management for Pregnant Smokers in Appalachia | Medicine |
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Estus, Steve,
PhD
| Safety and Target Engagement of Clusterin by Valproic Acid in Subjects with Intact Cognition: Proof of Concept for the Development of a Prevention Trial for Alzheimer's Disease | Medicine |
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Havens, Jennifer,
PhD
| Feasibility of Implementing an HIV Vaccine Initiative Among High-Risk Drug Users in Appalachia | Medicine |
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Panchatcharam, Manikandan,
PhD
| Functional Validation of PPAP2B as a Novel Risk for Coronary Artery Disease | Medicine |
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Yu, Guoqiang,
PhD
| Non-contact Diffuse Optical Quantification of Hemodynamic Contrast in Breast Tumor | Engineering |
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Zhu, Haining,
PhD
| Therapeutic Development for ALS Using Patient-Derived Induced Pluripotent Stem Cells | Medicine |
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Summer 2011 Awardees
| Investigator | Pilot Proposal Title | College |
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Blumenschein, Karen,
Pharm D
| The consumer's Perspective on the Chilling Effect | Pharmacy |
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Gedaly, Roberto,
MD
| Detection and Treatment of Liver Cancer Stem Cells In Hepatocellular Carcinoma | Medicine |
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Hanaoka, Beatriz Y,
MD
| The role of innate immune responses in muscle regeneration in patients with idiopathic inflammatory myopathies | Medicine |
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Lile, Joshua,
PhD
| Human Laboratory Evaluation of the Synthetic Cannabinoid Nabilone for Cannabis-Use Disorders | Medicine |
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Spring 2011 Awardees
| Investigator | Pilot Proposal Title | College |
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Abdel-Latif, Ahmed,
MD, MS
| Role of S1P and its receptors in the mobilization of BMSCs in the setting of myocardial ischemia and the potential therapeutic role of S1P agonists in myocardial regeneration | Medicine |
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Richard Eitel,
MD
| Cell Based Endothelium Activation Capacity (EAC) Sensor for the Diagnosis and Monitoring of Sepsis, Severe Sepsis and Septic Shock | Engineering |
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2010 Awardees
| Investigator | Pilot Proposal Title | College |
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Richard Andreatta,
PhD
| Central Control of Vocalization as a Function of Personality Type and Stress Reactivity | Health Sciences |
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Lumy Sawaki,
MD, PhD
| Facilitating gait recovery with transcranial direct current stimulation in chronic stroke: a feasibility study | Medicine |
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Liu Chunmin,
PhD
| Novel Wnt inhibitors for colon cancer prevention and therapeutics | Medicine |
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Jennifer McKeon,
PhD, ATC, CSCS
| Interscholastic sports injury surveillance and prevention in rural Kentucky: a pilot study | Health Sciences |
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Shelia Botts,
PharmD
| Quality of Public Mental Health Care in Kentucky | Pharmacy |
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Walter High,
MD, PhD
| Growth Hormone Deficiency and Brain Functioning after Traumatic Brain Injury | Medicine |
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Rita Patel,
PhD, CCC-SLP
| Clinical Measurement of Vocal Fold Impact Stress in Children | Health Sciences |
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Neelkamal Soares,
MD
| A Utilizing Video Data to Evaluate Childhood Disruptive Behavior Disorder | Medicine |
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Stephanie Rose,
MD
| Patient and Provider Attitudes Toward Obesity Care in the Primary Care Setting | Medicine |
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