Introduction to Cancer Somatic Mutation Analyses
Somatic mutations are a driving force for cancer development. The profiling of somatic mutations based on second-generation sequencing has provided an unprecedented opportunity to enhance the understanding of cancer biology and identify new drug targets. In this talk, I will provide a brief introduction to bioinformatics analyses of somatic mutation data, including the detection of somatic mutations, identification of significantly mutated genes, discovery of driver mutations, delineation of the temporal order of pathway mutations, and reconstruction of phylogenetic trees.
Presented by:
Chi Wang, PhD
Professor, Division of Cancer Biostatistics, Department of Internal Medicine, College of Medicine
Assistant Director for Bioinformatics, Biostatistics and Bioinformatics Shared Resource Facility, Markey Cancer Center
University of Kentucky
